Endocrine disruption of vitamin D activity by perfluoro-octanoic acid (PFOA)
نویسندگان
چکیده
منابع مشابه
Endocrine functions of vitamin D
The name “vitamin D” for the fat-soluble secosteroid cholecalciferol implies that humans need to take up this molecule via their diet since their own catabolism may not be able to produce it. In contrast, at UV-B (290e315 nm) exposure human skin is able to synthesize vitamin D on the basis of the cholesterol precursor 7dehydrocholesterol. Thus, insufficient exposure to sunlight in populations l...
متن کامل[Vitamin D and endocrine diseases].
Vitamin D insufficiency/deficiency has been worldwide reported in all age groups in recent years. It has been considered a Public Health matter since decreased levels of vitamin D has been related to several chronic diseases, as type 2 diabetes mellitus (T2DM), obesity and hypertension. Glucose intolerance and insulin secretion has been observed during vitamin D deficiency, both in animals and ...
متن کامل[The vitamin D endocrine system].
The vitamin D endocrine system comprises a group of 7-dehydrocholesterol-derived secosteroid molecules, including its active metabolite 1,25-dihydroxy-vitamin D (1,25(OH)(2)D), its precursors and other metabolites, its binding protein (DBP) and nuclear receptor (VDR), as well as cytochrome P450 complex enzymes participating in activation and inactivation pathways of those molecules. The biologi...
متن کاملUnexamined Endocrine Disruption? Pesticides Inhibit Prostaglandin Activity
that ubiquitous biologically active lipids called prostaglandins play in these developmental processes, although studies have found that prostaglandins help initiate male genital development. In this issue of EHP, researchers show that several structurally different endocrine-active pesticides suppress prostaglandin synthesis and signaling in mouse cells. “The research provides support for a ne...
متن کاملVitamin D endocrine system and osteoclasts
Vitamin D was discovered as an anti-rachitic agent preventing a failure in bone mineralization, but it is now established that the active form of vitamin D3 (1α,25(OH)2D3) induces bone resorption. Discovery of the receptor activator of nuclear factor -κB ligand (RANKL) uncovered the molecular mechanism by which 1α,25(OH)2D3 stimulates bone resorption. Treating osteoblastic cells with 1α,25(OH)2...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2020
ISSN: 2045-2322
DOI: 10.1038/s41598-020-74026-8